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Related Experiment Videos

Verapamil as a hypotensive agent under general anaesthesia.

R M Khan1, T Z Khan, S Hakim

  • 1Department of Anaesthesiology, JN Medical College, Aligarh Muslim University.

Journal of the Indian Medical Association
|September 1, 1990
PubMed
Summary

Intravenous verapamil administered during abdominal hysterectomy caused a dose-dependent decrease in mean arterial pressure and prolonged the P-R interval. Heart rate reduction was most pronounced at lower verapamil doses.

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Area of Science:

  • Cardiovascular Anesthesiology
  • Pharmacology

Background:

  • Abdominal hysterectomy is a common surgical procedure.
  • General anesthesia presents hemodynamic challenges.
  • Verapamil is a calcium channel blocker with potential cardiovascular effects.

Purpose of the Study:

  • To evaluate the hemodynamic effects of intravenous verapamil.
  • To determine the dose-dependent impact of verapamil on cardiovascular parameters.
  • To assess verapamil's safety and efficacy in patients undergoing abdominal hysterectomy.

Main Methods:

  • Thirty-six adult female patients undergoing abdominal hysterectomy were enrolled.
  • Patients received intravenous verapamil in bolus doses of 50, 60, or 75 micrograms/kg.
  • Hemodynamic parameters including mean arterial pressure, heart rate, and P-R interval were monitored.

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Main Results:

  • A dose-dependent decrease in mean arterial pressure was observed.
  • An increase in the P-R interval, indicating slowed atrioventricular conduction, was noted.
  • The most significant fall in heart rate occurred in the lower dose groups (50 and 60 micrograms/kg).

Conclusions:

  • Intravenous verapamil administration during abdominal hysterectomy results in predictable hemodynamic changes.
  • The observed effects are dose-dependent, with lower doses causing a greater reduction in heart rate.
  • Verapamil's impact on mean arterial pressure and P-R interval should be considered during anesthetic management.