Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Heart Failure V: Medical Management

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...

Cardiomyopathy VI: Nursing Management

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same author

A Lightweight Machine Learning Framework for Post-Stroke Gait Abnormality Classification Using Wearable Gyroscope Features.

Sensors (Basel, Switzerland)·2026

Same author

Sex determines cardiac and renal Vulnerability to chronic hemoglobin toxicity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Same author

Intermittent Hypoxia Associated with Sleep Apnea Disrupts Microvascular Hemodynamics and Oxygen Delivery.

Communications biology·2026

Same author

Acellular Hemoglobin Impairs Cardiomyocyte Excitation-Contraction Coupling.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026

Same author

Modulatory effects of exogenous estradiol during endotoxemia.

The international journal of biochemistry & cell biology·2026

Same journal

Diagnostic accuracy of emergency department triage systems for predicting clinical severity: A systematic review and meta-analysis of five-level triage scales.

The American journal of emergency medicine·2026

Same journal

Methanol toxicity from inhalational abuse of a methyl acetate-containing nail polish remover.

The American journal of emergency medicine·2026

Same journal

Regarding strategies, feasibility of implementations and results of HIV screening in emergency departments.

The American journal of emergency medicine·2026

Same journal

Rocuronium dosing for rapid sequence intubation: A retrospective analysis in ED and ICU settings.

The American journal of emergency medicine·2026

Same journal

Clinical features of adults with undiagnosed acute leukemia in the emergency department: A descriptive study.

The American journal of emergency medicine·2026

Same journal

Occult intraperitoneal gynecological hemorrhage: An under-evaluated source of hemoperitoneum after blunt trauma.

The American journal of emergency medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 19, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Improving cardiac function with new-generation plasma volume expanders.

Surapong Chatpun¹, Parimala Nacharaju, Pedro Cabrales

¹Department of Bioengineering, University of California-San Diego, La Jolla, CA 92093, USA.

The American Journal of Emergency Medicine

|August 8, 2012

Summary

This summary is machine-generated.

Polyethylene glycol-human serum albumin (PEG-HSA) improved cardiac function in hemodilution and shock models. This novel plasma expander reduced cardiac load and enhanced contractile function compared to Dextran 70.

More Related Videos

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Related Experiment Videos

Last Updated: May 19, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Area of Science:

Cardiovascular Physiology
Biomaterials Science
Emergency Medicine

Background:

Plasma expanders (PEs) are crucial for maintaining blood volume.
Polyethylene glycol (PEG) conjugated to human serum albumin (HSA) enhances PE properties.
PEG-HSA increases size, weight, and colloidal osmotic pressure with minimal viscosity changes.

Purpose of the Study:

To test if PEG-HSA improves cardiac function during hemodilution and hemorrhagic shock.
To compare PEG-HSA's efficacy against conventional colloidal PEs like Dextran 70 (Dx70).

Main Methods:

Utilized two experimental models: moderate hemodilution and resuscitation from hemorrhagic shock.
Employed a miniaturized pressure-volume conductance catheter for left ventricular analysis.
Evaluated cardiac indices derived from pressure-volume measurements.

Main Results:

PEG-HSA significantly increased cardiac output, stroke volume, and stroke work compared to Dx70.
Systemic vascular resistance was decreased by PEG-HSA in both models.
Improvements in cardiac function and reduced left ventricle ejection impedance were sustained.

Conclusions:

PEG-HSA reduces cardiac load and enhances contractile function compared to Dx70.
This suggests PEG-HSA is a promising plasma expander with favorable hemodynamic effects.
Heart function evaluation is critical for assessing new plasma expanders.