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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Tumor Progression02:07

Tumor Progression

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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Cholecystitis01:20

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Related Experiment Video

Updated: May 19, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
07:35

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

Cholesterol and breast cancer development.

Christiane Danilo1, Philippe G Frank

  • 1Department of Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Current Opinion in Pharmacology
|August 8, 2012
PubMed
Summary

Cholesterol influences breast cancer development by regulating cell growth and migration. Targeting cholesterol metabolism offers a new therapeutic strategy for breast cancer treatment.

Area of Science:

  • Oncology
  • Biochemistry
  • Environmental Health

Background:

  • Breast cancer is the most prevalent cancer globally.
  • Environmental factors, including cholesterol, are investigated for their role in breast cancer.
  • Epidemiological studies show inconsistent links between plasma cholesterol and breast cancer risk.

Purpose of the Study:

  • To investigate the role of cholesterol in breast cancer.
  • To explore cholesterol metabolism as a potential therapeutic target for breast cancer.

Main Methods:

  • Review of epidemiological studies.
  • Analysis of laboratory and in vivo studies on cholesterol's effects on breast cancer cells and tumor growth in mouse models.

Main Results:

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An Ex vivo Model to Study Hormone Action in the Human Breast
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An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

Related Experiment Videos

Last Updated: May 19, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
07:35

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

An Ex vivo Model to Study Hormone Action in the Human Breast
12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

Published on: January 8, 2015

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

  • Laboratory studies demonstrate cholesterol regulates proliferation, migration, and signaling pathways in breast cancer.
  • In vivo studies indicate plasma cholesterol levels influence tumor growth in mouse models.
  • Evidence suggests a role for cholesterol in breast cancer development.

Conclusions:

  • Cholesterol is implicated as a contributing factor in breast cancer development.
  • Cholesterol and its metabolic pathways represent novel therapeutic targets for breast cancer therapy.