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Hybridoma Technology

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...

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Updated: May 19, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

Hyperhaploid plasma cell myeloma.

Veronica T Hoctor¹, Lynda J Campbell

¹Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Melbourne, Fitzroy, Victoria, Australia. Veronica.HOCTOR@svhm.org.au

Cancer Genetics

|August 8, 2012

Summary

This summary is machine-generated.

This study identifies a rare form of plasma cell myeloma (PCM) with hyperhaploid karyotypes. These findings suggest hyperhaploidy may represent a distinct cytogenetic entity in PCM, potentially impacting prognosis.

Area of Science:

Hematology
Cytogenetics
Oncology

Background:

Plasma cell myeloma (PCM) exhibits chromosome abnormalities in about one-third of cases.

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PCM is broadly classified into hyperdiploid and non-hyperdiploid groups based on aneuploidy.

Hypodiploid PCM is linked to a poorer prognosis, with modal numbers typically exceeding 40.