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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Updated: May 19, 2026

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

Human disease modeling with induced pluripotent stem cells.

Alan Trounson1, Kelly A Shepard, Natalie D DeWitt

  • 1California Institute for Regenerative Medicine, San Francisco, CA 94107, USA. atrounson@cirm.ca.gov

Current Opinion in Genetics & Development
|August 8, 2012
PubMed
Summary

Cellular programming enables patient-specific disease modeling by creating pluripotent stem cells from individuals. This approach facilitates studying genetic disease mechanisms and screening new therapies.

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Area of Science:

  • Biotechnology and Regenerative Medicine
  • Genomics and Personalized Medicine
  • Disease Modeling

Background:

  • Cellular programming allows for the generation of diverse human cell types in culture.
  • Many diseases have a genetic basis that varies significantly between individuals.
  • Existing disease models often lack patient-specific genetic relevance.

Purpose of the Study:

  • To introduce and highlight the potential of patient-derived cellular models for disease research.
  • To explore how cellular programming can create personalized models for studying genetic diseases.
  • To showcase the utility of these models in understanding disease mechanisms and therapeutic development.

Main Methods:

  • Reprogramming patient somatic cells into induced pluripotent stem cells (iPSCs).
  • Directing iPSCs to differentiate into specific cell types affected by disease.
  • Analyzing these patient-specific cellular models for disease-related characteristics.

Main Results:

  • Over fifty patient-specific disease models have been successfully generated.
  • These models recapitulate the genetic variations of individual donors.
  • Demonstrated potential for investigating cellular-molecular pathology and genetic influences.

Conclusions:

  • Cellular programming offers a powerful platform for personalized disease modeling.
  • These models are crucial for understanding the interplay of genetics and environment in disease.
  • Patient-specific cellular models represent a significant advancement for drug screening and therapeutic discovery.