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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: May 19, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

The development of pluripotent stem cells.

Paul J Gokhale1, Peter W Andrews

  • 1Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.

Current Opinion in Genetics & Development
|August 8, 2012
PubMed
Summary

Pluripotent stem cells, crucial for medicine, originated from teratoma tumor research. Understanding these cells, including embryonic stem (ES) and induced pluripotent stem (iPS) cells, reveals connections to cancer biology.

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A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
11:38

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

Published on: October 4, 2024

Related Experiment Videos

Last Updated: May 19, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
11:38

A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

Published on: October 4, 2024

Area of Science:

  • Stem cell biology
  • Developmental biology
  • Cancer biology

Background:

  • Pluripotent stem cells hold promise for medical and pharmaceutical applications.
  • The study of teratomas, a rare tumor type, provided early insights into stem cell biology.
  • The identification of teratoma stem cells linked to early embryonic development.

Purpose of the Study:

  • To explore the origins of pluripotent stem cell research.
  • To connect teratoma biology to the development of embryonic stem (ES) and induced pluripotent stem (iPS) cells.
  • To investigate the relationship between prolonged stem cell culture and cancer biology.

Main Methods:

  • Review of historical research linking teratomas to stem cell development.
  • Analysis of the progression from mouse to human pluripotent stem cell models.
  • Examination of genetic changes and culture adaptation in stem cells.

Main Results:

  • Teratoma biology is foundational to understanding pluripotent stem cells.
  • Embryonic stem (ES) and induced pluripotent stem (iPS) cell development was enabled by teratoma research.
  • Prolonged culture of stem cells reveals genetic changes and adaptations relevant to cancer.

Conclusions:

  • The study of teratomas is critical for advancing pluripotent stem cell applications.
  • Understanding stem cell differentiation control is key for therapeutic use.
  • Recent findings highlight the link between stem cell culture adaptation and cancer biology, necessitating further investigation.