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Updated: May 19, 2026

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Published on: September 7, 2017
PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes
Jinsuk Kang1, Sundeep Kalantry, Anjana Rao
1La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Abstract:
In zygotes, a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division, concomitantly with the appearance of modified forms of 5-methylcytosine. The adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Nakamura et al. recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.
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