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Remifentanil use in pediatric scoliosis surgery-an effective alternative to morphine (a retrospective study)
Ibrahim Abu-Kishk1, Roei Hod-Feins, Yoram Anekstein
1Pediatric Intensive Care Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel. fredricag@asaf.health.gov.il
Insights
Remifentanil anesthesia in pediatric scoliosis surgery leads to shorter operating times and faster extubation. This approach reduces intensive care unit needs without increasing complication rates, making it a safe and effective option.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Spinal Fusion
Background:
- Remifentanil offers unique properties for pediatric anesthesia.
- Concerns exist regarding its high potency and limited clinical trials in children.
- Adverse events are a consideration in pediatric potent anesthetic use.
Purpose of the Study:
- To evaluate the efficacy of remifentanil in pediatric scoliosis surgery.
- To compare remifentanil with morphine anesthesia in this patient population.
- To consolidate preliminary findings on remifentanil's use in pediatric spinal fusion.
Main Methods:
- Retrospective review of medical charts for children undergoing spinal fusion (1998-2007).
- Patients divided into remifentanil and morphine anesthesia groups.
- Comparison of demographic, surgical, and postoperative data.
Main Results:
- Remifentanil group showed significantly earlier extubation (all patients) versus morphine group (2/84 patients).
- Shorter surgical duration observed in the remifentanil group (5.6 vs. 7.14 hours).
- Fewer remifentanil patients required intensive care, with no significant increase in major or minor complications.
Conclusions:
- Remifentanil anesthesia can reduce operating time and facilitate early extubation in pediatric scoliosis surgery.
- It decreases the need for intensive care hospitalization post-surgery.
- Remifentanil use is associated with comparable safety profiles to morphine regarding complications.
Purpose:
The unique properties of remifentanil make it ideal for pediatric use despite a lack of wide randomized clinical trials and fear of adverse events due to its high potency. We aimed to consolidate preliminary conclusions regarding the efficacy of remifentanil use in pediatric scoliosis surgery.
Materials And Methods:
The medical charts of children with idiopathic scoliosis who underwent primary spinal fusion between 1998 and 2007 at a large tertiary university-affiliated hospital were retrospectively reviewed and divided into two groups according to anesthetic regime (remifentanil vs. morphine). Demographic, surgery-related details and immediate postoperative course were recorded and compared.
Results:
All 36 remifentanil children were extubated shortly after termination of surgery, compared to 2 of the 84 patients in the morphine group. The remaining patients in the morphine group were extubated hours after surgery [5.4 hours; standard deviation (SD) 1.7 hours]. Six remifentanil children were spared routine intensive care hospitalization (vs. 2 morphine children-significant difference). Shorter surgeries [5.6 hours (SD 1.82 hours) vs. 7.14 hours (SD 2.15 hours); p=0.0004] were logged for the remifentanil group. To achieve controlled hypotension during surgery, vasodilator agents were used in the morphine group only. A comparison of early postoperative major or minor complication rates (including neurological and pulmonary complications) between the two groups yielded no significant differences.
Conclusion:
Remifentanil use can shorten operating time and facilitate earlier spontaneous ventilation and extubation, with less of a need for intensive care hospitalization and no increase in significant complications.
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