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Updated: May 19, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Systemic therapy for metastatic renal cell carcinoma]

M W Kramer1, S Steffens, C von Klot

  • 1Klinik für Urologie und Urologische Onkologie Medizinische Hochschule Hannover, Germany.

Aktuelle Urologie
|August 8, 2012
PubMed

Insights

Targeted therapies, including tyrosine kinase (TK) and mTOR inhibitors, have replaced cytokine-based treatments for advanced renal cell carcinoma. This review covers current first- and second-line systemic therapies and sequential treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Advances in understanding renal cell carcinoma (RCC) pathogenesis and prognosis.
  • Shift from cytokine-based therapies to targeted agents for metastatic RCC.

Purpose of the Study:

  • To review the current state of systemic therapy for renal cell carcinoma.
  • To discuss first- and second-line treatment options.
  • To explore sequential therapy and side effect management.

Main Methods:

  • Literature review of recent advancements in RCC systemic therapy.
  • Analysis of targeted therapeutic agents, including tyrosine kinase (TK) and mTOR inhibitors.
  • Discussion of clinical trial data and treatment guidelines.

Main Results:

  • Targeted therapies (TK and mTOR inhibitors) are now standard for advanced RCC.
  • Established efficacy of specific agents in first- and second-line settings.
  • Growing importance of sequential treatment strategies to optimize outcomes.

Conclusions:

  • Systemic therapy for advanced renal cell carcinoma has been revolutionized by targeted agents.
  • Optimal sequencing of therapies is crucial for maximizing patient benefit.
  • Consideration of side effect profiles is essential for effective treatment plans.

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