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Updated: May 19, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Fractional flow reserve: the past, present and future

Jeong-Eun Kim1, Bon-Kwon Koo

  • 1Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.

Korean Circulation Journal
|August 8, 2012
PubMed

Insights

Fractional flow reserve (FFR) measurement provides objective evidence of ischemia, improving revascularization decisions for coronary artery disease. FFR-guided strategies are more effective than angiography alone.

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Diagnostic imaging

Background:

  • Coronary artery stenosis revascularization decisions often rely on angiography.
  • Angiography alone has poor correlation with the functional significance of coronary lesions.
  • Objective evidence of ischemia is crucial for guiding revascularization.

Purpose of the Study:

  • To highlight the importance of objective ischemia evidence in revascularization decisions.
  • To introduce Fractional Flow Reserve (FFR) as a key diagnostic parameter.
  • To compare FFR-guided versus angiography-guided revascularization strategies.

Main Methods:

  • Measurement of Fractional Flow Reserve (FFR) during invasive procedures.
  • Assessment of coronary stenosis functional significance using FFR.
  • Comparison of clinical outcomes between FFR-guided and angiography-guided strategies.

Main Results:

  • FFR provides a reliable assessment of the functional significance of coronary stenosis.
  • FFR-guided revascularization strategies demonstrate superior effectiveness compared to angiography-guided approaches.
  • Emerging FFR-based technologies are poised for clinical integration.

Conclusions:

  • Revascularization for coronary artery stenosis requires objective ischemia assessment.
  • FFR is a valuable tool for functional assessment of coronary lesions.
  • FFR-guided strategies offer improved outcomes in patients with coronary artery disease.

Keywords:
Coronary artery diseaseFractional flow reserve, myocardiolIschemia

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