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Updated: May 19, 2026

06:32
Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Fractional flow reserve: the past, present and future.
1Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.
Korean Circulation Journal
|August 8, 2012
Summary
Fractional flow reserve (FFR) measurement provides objective evidence of ischemia, improving revascularization decisions for coronary artery disease. FFR-guided strategies are more effective than angiography alone.
Area of Science:
- Cardiovascular medicine
- Interventional cardiology
- Diagnostic imaging
Background:
- Coronary artery stenosis revascularization decisions often rely on angiography.
- Angiography alone has poor correlation with the functional significance of coronary lesions.
- Objective evidence of ischemia is crucial for guiding revascularization.
Purpose of the Study:
- To highlight the importance of objective ischemia evidence in revascularization decisions.
- To introduce Fractional Flow Reserve (FFR) as a key diagnostic parameter.
- To compare FFR-guided versus angiography-guided revascularization strategies.
Main Methods:
- Measurement of Fractional Flow Reserve (FFR) during invasive procedures.
- Assessment of coronary stenosis functional significance using FFR.
- Comparison of clinical outcomes between FFR-guided and angiography-guided strategies.
Main Results:
- FFR provides a reliable assessment of the functional significance of coronary stenosis.
- FFR-guided revascularization strategies demonstrate superior effectiveness compared to angiography-guided approaches.
- Emerging FFR-based technologies are poised for clinical integration.
Conclusions:
- Revascularization for coronary artery stenosis requires objective ischemia assessment.
- FFR is a valuable tool for functional assessment of coronary lesions.
- FFR-guided strategies offer improved outcomes in patients with coronary artery disease.
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