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Related Experiment Video

Updated: May 19, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

IgM multiple myeloma presenting with bleeding tendency: a case report with immunophenotype analysis.

Ling Zheng1, Zhiyong Zeng, Junfang Lin

  • 1Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.

Oncology Letters
|August 8, 2012
PubMed
Summary

IgM Multiple Myeloma (MM) is rare and aggressive. Distinguishing it from Waldenstrom

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • IgM Multiple Myeloma (MM) is a rare lymphoproliferative disorder with an aggressive course.
  • Diagnosis can be challenging due to similarities with Waldenstrom's Macroglobulinemia (WM), especially with atypical presentations.
  • Accurate differentiation is critical as MM and WM require distinct treatment strategies and have different prognoses.

Purpose of the Study:

  • To report a case of IgM MM presenting with bleeding tendency.
  • To highlight the importance of immunophenotypic analysis in differentiating IgM MM from WM.
  • To emphasize the diagnostic utility of flow cytometry and immunohistochemistry in complex cases.

Main Methods:

  • Case report of a patient with IgM MM.
  • Immunophenotype analysis of bone marrow cells using flow cytometry.

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

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Last Updated: May 19, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

  • Immunohistochemistry staining for confirmation of plasma cell markers.

    • Main Results:

    • Bone marrow cells showed a plasma cell phenotype: monoclonal cytoplasmic Igλ, CD38+, CD138+.
    • Cells lacked typical B-cell antigens (CD19, CD20, CD22) characteristic of WM.
    • Diagnosis of IgM MM was confirmed based on these findings.

    Conclusions:

    • Immunophenotypic evaluation is crucial for accurate diagnosis of IgM MM, particularly in atypical cases.
    • Flow cytometry and immunohistochemistry provide definitive markers to distinguish IgM MM from WM.
    • This case underscores the significance of detailed diagnostic workup for rare hematologic malignancies.