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Updated: May 19, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Multiple sclerosis and CCSVI: a population-based case control study.

Francesco Patti1, Alessandra Nicoletti, Carmela Leone

  • 1Department DANA GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy.

Plos One
|August 8, 2012
PubMed
Summary
This summary is machine-generated.

Chronic cerebrospinal venous insufficiency (CCSVI) is more common in multiple sclerosis (MS) patients, particularly those with advanced disease. This suggests a potential link between CCSVI and MS-related disability.

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Published on: July 19, 2019

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Last Updated: May 19, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neurology
  • Vascular Medicine

Background:

  • Chronic cerebrospinal venous insufficiency (CCSVI) has been hypothesized as a contributing factor in multiple sclerosis (MS).
  • Further investigation is needed to establish a definitive association between CCSVI and MS.

Purpose of the Study:

  • To investigate the association between CCSVI and MS using a population-based control study.
  • To determine if CCSVI prevalence differs among MS patients, clinically isolated syndrome (CIS) patients, other neurological disease (OND) patients, and healthy controls.

Main Methods:

  • A cohort of 148 incident MS patients, 20 CIS patients, 40 OND patients, and 172 healthy controls were recruited.
  • Transcranial and Echo Color Doppler were used to assess CCSVI, defined by the presence of ≥2 venous hemodynamic criteria.
  • A total of 380 subjects underwent Doppler assessment.

Main Results:

  • CCSVI was diagnosed in 18.9% of MS patients, significantly higher than in controls (6.4%).
  • A significant association was found between MS and CCSVI (OR=3.41, p=0.001).
  • CCSVI prevalence increased with disease duration and was more pronounced in secondary progressive (SP) and primary progressive (PP) MS forms compared to relapsing-remitting (RR) MS.

Conclusions:

  • The study found a higher frequency of CCSVI in MS patients.
  • CCSVI appears more prevalent in advanced stages of MS, suggesting a potential role in MS disability.
  • These findings support a possible link between CCSVI and the progression of multiple sclerosis.