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Bioavailability of ascorbic acid in horses.

D H Snow1, M Frigg

  • 1Animal Health Trust, Newmarket, Suffolk, UK.

Journal of Veterinary Pharmacology and Therapeutics
|December 1, 1990
PubMed
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Investigating ascorbic acid bioavailability in thoroughbreds revealed varied results. Intramuscular injections showed high bioavailability, while oral supplementation effects on plasma concentrations require further study.

Area of Science:

  • Veterinary Medicine
  • Animal Nutrition
  • Pharmacokinetics

Background:

  • Ascorbic acid (vitamin C) is crucial for equine health.
  • Understanding its bioavailability is key for effective supplementation strategies in thoroughbreds.

Purpose of the Study:

  • To evaluate the bioavailability of ascorbic acid in thoroughbreds via different administration routes (intramuscular, subcutaneous, oral).
  • To compare the efficacy of crystalline ascorbic acid versus ascorbyl palmitate for oral supplementation.

Main Methods:

  • Intramuscular and subcutaneous injections of ascorbic acid preparations were administered.
  • Oral administration of crystalline ascorbic acid and ascorbyl palmitate was conducted in a cross-over trial.
  • Plasma ascorbic acid concentrations were monitored over time.

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Main Results:

  • Intramuscular injection demonstrated high bioavailability (up to 95%), while subcutaneous injection showed 82% bioavailability but caused irritation.
  • Oral administration of ascorbyl palmitate led to a greater increase in plasma ascorbic acid compared to crystalline ascorbic acid.
  • Individual variations in response and unexpected decreases in plasma levels post-supplementation were observed.

Conclusions:

  • Intramuscular administration of ascorbic acid is highly bioavailable in thoroughbreds.
  • Ascorbyl palmitate may be a more effective oral form than crystalline ascorbic acid.
  • Further research is needed to understand the variability and potential decreases in plasma ascorbic acid levels after oral supplementation.