Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Plasminogen activator in leukemic cell homogenate].

H Wada1, Z Ogasawara, Y Kumeda

  • 12nd Department of Internal Medicine, Mie University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|November 1, 1990
PubMed
Summary

Leukemic cells show increased plasminogen activators (PA), particularly in myeloblastic leukemia. Elevated PA and its stimulator in leukemic cells may contribute to disseminated intravascular coagulation (DIC) and hypofibrinogenemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First report of hepatobiliary <i>Mycobacterium avium</i> infection developing obstructive jaundice in a patient with neutralizing anti-interferon-gamma autoantibodies.

New microbes and new infections·2018
Same author

Anti-RNA polymerase III antibody positive limited cutaneous systemic sclerosis with cryoglobulin-induced digital gangrene.

Clinical and experimental dermatology·2016
Same author

Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.

Oncogene·2015
Same author

ADAM12-cleaved ephrin-A1 contributes to lung metastasis.

Oncogene·2013
Same author

Serum lipid levels are positively associated with non-erosive reflux disease, but not with functional heartburn.

Neurogastroenterology and motility·2010
Same author

Decreased gene expression of insulin signaling genes in insulin sensitive tissues of obese cats.

Veterinary research communications·2008

Area of Science:

  • Hematology
  • Oncology
  • Biochemistry

Context:

  • Fibrinolysis is crucial for hemostasis.
  • Leukemic cells can influence coagulation and fibrinolysis.
  • Understanding these interactions is vital for managing leukemia-associated complications.

Purpose:

  • To investigate the levels and activity of plasminogen activators (PA) and their inhibitors in leukemic cells.
  • To determine the role of PA and PA stimulators in leukemic cells concerning disseminated intravascular coagulation (DIC).

Summary:

  • Plasminogen activators (PA) were significantly lower in normal cells but increased in lymphoblastic and myeloblastic leukemia cells.
  • The tissue-type PA (t-PA)/urokinase-type PA (u-PA) ratio was approximately 2.0 in leukemic cells.
  • Elevated PA inhibitor (PAI)-II was observed in acute myeloid leukemia subtypes (AMMoL, AMoL), potentially affecting PA assays.

Related Experiment Videos

  • Leukemic cell homogenates stimulated t-PA activity, and increased PA activity and antigen were noted in patients with DIC.

    • Impact:

    • Leukemic cells possess distinct fibrinolytic profiles.
    • PA and PA stimulators within leukemic cells may be key factors in developing hypofibrinogenemia and DIC in leukemia patients.
    • This research highlights potential therapeutic targets for managing bleeding complications in leukemia.