Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

26.7K
Overview
26.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

223
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
223
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

293
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
293

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drivers of disparities in asthma exacerbation and healthcare utilization: a quantitative analysis of neighborhood deprivation in Southern California, United States.

Preventive medicine reports·2026
Same author

The relationship between maternal non-narcotic analgesics allergy labels and maternal and fetal outcomes: results from a large, administrative cohort.

The journal of allergy and clinical immunology. In practice·2026
Same author

Cohort vs case-control design for transformer-based prediction of asthma exacerbations in mild asthma.

NPJ digital medicine·2026
Same author

Machine learning prediction of asthma and allergic rhinitis in children with early-onset atopic dermatitis.

The Journal of allergy and clinical immunology·2026
Same author

Standardizing RNA-seq Analysis of Fungal Pathogens Using BRC-Analytics and Agentic AI: A <i>Candidozyma auris</i> Case Study.

bioRxiv : the preprint server for biology·2026
Same author

Statins associate with reduced asthma exacerbation risk in Black and obese patients with mild asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same journal

Tamoxifen-driven neutrophil reprogramming protects from pulmonary Granulibacter bethesdensis infection in chronic granulomatous disease.

The Journal of allergy and clinical immunology·2026
Same journal

Clinical and transcriptomic characterization of mixed granulocytic COPD phenotype.

The Journal of allergy and clinical immunology·2026
Same journal

Dupilumab outcomes in pediatric asthma by early eosinophil status: post hoc analysis of VOYAGE/EXCURSION.

The Journal of allergy and clinical immunology·2026
Same journal

Maternal antibiotic exposure alters the newborn metabolomic profile and increases the risk of respiratory infections in offspring: a 13-year longitudinal birth cohort study.

The Journal of allergy and clinical immunology·2026
Same journal

Selective Elimination of Mast Cells via Siglec-6-Targeted Nanodelivery of Drug Payload.

The Journal of allergy and clinical immunology·2026
Same journal

Loss of epidermal miR-149 sensitizes to skin inflammation.

The Journal of allergy and clinical immunology·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.1K

Anaphylaxis during pregnancy.

F Estelle R Simons1, Michael Schatz

  • 1Department of Pediatrics & Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. lmcniven@hsc.mb.ca

The Journal of Allergy and Clinical Immunology
|August 9, 2012
PubMed
Summary
This summary is machine-generated.

Anaphylaxis during pregnancy poses severe risks to mothers and infants. Prompt management with epinephrine and oxygen is crucial, with specialists aiding in prevention strategies.

More Related Videos

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

17.0K
Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

25.3K

Related Experiment Videos

Last Updated: May 5, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.1K
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

17.0K
Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

25.3K

Area of Science:

  • Obstetrics and Gynecology
  • Allergy and Immunology
  • Critical Care Medicine

Background:

  • Anaphylaxis during pregnancy, labor, and delivery presents significant risks to both mother and infant.
  • Symptoms can range from itching and pain to severe complications like fetal distress and preterm labor.

Purpose of the Study:

  • To outline the risks, symptoms, and management strategies for anaphylaxis in pregnant individuals.
  • To emphasize the role of allergy specialists in pre-pregnancy risk assessment and prevention.

Main Methods:

  • Review of clinical presentation and common etiologies of anaphylaxis during pregnancy and delivery.
  • Discussion of critical management interventions including prompt epinephrine administration, oxygen therapy, and maternal positioning.
  • Consideration of diagnostic procedures and immunomodulatory treatments in pregnant patients.

Main Results:

  • Common triggers include beta-lactam antibiotics and natural rubber latex during labor and delivery.
  • Effective management requires prompt epinephrine, oxygen, left-sided positioning, and maintaining maternal blood pressure.
  • Pre-pregnancy risk assessment and allergen avoidance are key preventive strategies.

Conclusions:

  • Anaphylaxis in pregnancy necessitates immediate and specific medical interventions for optimal outcomes.
  • Allergy specialists play a vital role in preventing and managing anaphylaxis in women of childbearing age.
  • Further interdisciplinary research on pregnancy-related anaphylaxis is warranted.