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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Vitamin D insufficiency and deficiency in children with chronic kidney disease

Jameela Abdulaziz Kari1, Sherif Mohamed El Desoky, Salah Mohamed El-Morshedy

  • 1Department of Pediatrics, King Abdulaziz University, Jeddah, Saudi Arabia. jkari@doctors.org.uk

Annals of Saudi Medicine
|August 9, 2012
PubMed

Insights

Children with chronic kidney disease (CKD) have significantly lower vitamin D levels. Vitamin D insufficiency and deficiency are more common in pediatric CKD patients, highlighting a critical health concern.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Public Health

Background:

  • Hypovitaminosis D is prevalent in general populations.
  • Children with chronic kidney disease (CKD) face elevated risks of complications due to vitamin D deficiency.
  • This study investigated vitamin D status in pediatric CKD patients.

Purpose of the Study:

  • To determine the frequency of vitamin D insufficiency and deficiency in children with varying stages of CKD.
  • To compare vitamin D levels between children with CKD and healthy controls.
  • To explore correlations between vitamin D levels, CKD stage, and parathyroid hormone (iPTH).

Main Methods:

  • A case-control study was conducted at a university hospital.
  • Blood samples from children with CKD and controls were analyzed for vitamin D3, iPTH, and renal function markers.
  • Statistical analyses included correlations and associations between vitamin D levels, CKD stage, and iPTH.

Main Results:

  • Children with CKD exhibited significantly lower vitamin D levels compared to controls (17.5 vs. 21.0 ng/mL).
  • High frequencies of vitamin D insufficiency (45.0%), deficiency (30.0%), and severe deficiency (12.5%) were observed in pediatric CKD patients.
  • Significant negative correlation found between vitamin D3 and iPTH levels (r=-0.27, P=.01), and associations between vitamin D3 deficiency and reduced glomerular filtration rate.

Conclusions:

  • Vitamin D insufficiency and deficiency are significantly more frequent in children with CKD.
  • Lower vitamin D levels in pediatric CKD patients correlate with disease severity and elevated iPTH.
  • These findings underscore the importance of monitoring and managing vitamin D status in children with CKD.
Abstract

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