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A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
Lung function as a risk factor for subarachnoid hemorrhage: a prospective cohort study.
Martin Söderholm1, Elisabet Zia, Bo Hedblad
1Cardiovascular Epidemiology Research Group, SUS Malmö, CRC, 20502 Malmö, Sweden.
Stroke
|August 9, 2012
Summary
Reduced lung function, indicated by low forced expiratory volume in 1 second (FEV1) and FEV1/FVC ratio, significantly increases the risk of subarachnoid hemorrhage (SAH). This association holds true even when accounting for other risk factors like smoking.
Area of Science:
- Neurology
- Pulmonology
- Epidemiology
Background:
- The causes of subarachnoid hemorrhage (SAH) are not fully understood.
- Reduced lung function is a known predictor of cardiovascular disease.
- The link between lung function and SAH risk was previously unknown.
Purpose of the Study:
- To investigate the association between lung function parameters and the incidence of subarachnoid hemorrhage (SAH).
- To determine if reduced lung function is an independent risk factor for SAH.
Main Methods:
- A prospective cohort study involving 20,534 men and 7,237 women examined between 1974 and 1992.
- Spirometry was used to assess lung function, including forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio.
- SAH incidence was tracked over a mean follow-up of 26 years, with adjustments for confounding factors.
Main Results:
- A total of 145 SAH cases were recorded during the follow-up period.
- The lowest quartile of FEV1 was associated with a 2.24-fold increased hazard ratio for SAH (P=0.014).
- The lowest quartile of FEV1/FVC ratio was linked to a 1.92-fold increased hazard ratio for SAH (P=0.003), independent of smoking.
Conclusions:
- Low baseline lung function, specifically reduced FEV1 and FEV1/FVC ratio, is identified as a significant risk factor for subarachnoid hemorrhage (SAH).
- This risk is independent of smoking status, suggesting a direct link between pulmonary health and SAH.
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