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Grasping multiple sclerosis: do quantitative motor assessments provide a link between structure and function?
R Reilmann1, F Holtbernd, R Bachmann
1Department of Neurology, University Clinic Muenster (UKM), Westfaelische-Wilhelms-University Muenster, Albert-Schweitzer Campus 1, Building A1, 48149 Muenster, Germany. r.reilmann@uni-muenster.de
Grip-force variability (GFV) offers an objective measure for motor disability in multiple sclerosis (MS), correlating with clinical scores and brain changes. This quantitative method could enhance clinical trials by supplementing the Expanded Disability Status Scale (EDSS).
Area of Science:
- Neuroscience
- Biomedical Engineering
- Clinical Neurology
Background:
- Motor disability is a key challenge in multiple sclerosis (MS), often assessed using the subjective Expanded Disability Status Scale (EDSS).
- Objective, quantitative measures are needed to supplement the EDSS in MS clinical trials.
- Previous research indicated increased grip-force variability (GFV) in MS patients.
Purpose of the Study:
- To investigate if increased GFV in MS correlates with clinical disability (EDSS).
- To determine if GFV correlates with microstructural brain changes measured by diffusion tensor imaging (DTI).
- To explore GFV as a potential objective biomarker for MS motor dysfunction.
Main Methods:
- GFV was measured during a grasping and lifting task in 27 MS patients and 23 controls using a force transducer grip device.
- Clinical disability was assessed using the Expanded Disability Status Scale (EDSS) by experienced neurologists.
- Diffusion tensor imaging (DTI) at 3T was used to measure fractional anisotropy (FA) in cerebral white matter.
Main Results:
- GFV was significantly increased in MS patients compared to controls.
- Increased GFV correlated with reduced fractional anisotropy (FA) in white matter near the somatosensory and visual cortex.
- GFV also showed a significant correlation with the EDSS scores.
Conclusions:
- GFV is an objective measure of motor dysfunction in MS.
- GFV is linked to both clinical disability (EDSS) and underlying white matter microstructural changes.
- GFV warrants further investigation as a supplementary tool to the EDSS in MS clinical trials, particularly in proof-of-concept studies.
