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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Grasping multiple sclerosis: do quantitative motor assessments provide a link between structure and function?

R Reilmann1, F Holtbernd, R Bachmann

  • 1Department of Neurology, University Clinic Muenster (UKM), Westfaelische-Wilhelms-University Muenster, Albert-Schweitzer Campus 1, Building A1, 48149 Muenster, Germany. r.reilmann@uni-muenster.de

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Summary
This summary is machine-generated.

Grip-force variability (GFV) offers an objective measure for motor disability in multiple sclerosis (MS), correlating with clinical scores and brain changes. This quantitative method could enhance clinical trials by supplementing the Expanded Disability Status Scale (EDSS).

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Clinical Neurology

Background:

  • Motor disability is a key challenge in multiple sclerosis (MS), often assessed using the subjective Expanded Disability Status Scale (EDSS).
  • Objective, quantitative measures are needed to supplement the EDSS in MS clinical trials.
  • Previous research indicated increased grip-force variability (GFV) in MS patients.

Purpose of the Study:

  • To investigate if increased GFV in MS correlates with clinical disability (EDSS).
  • To determine if GFV correlates with microstructural brain changes measured by diffusion tensor imaging (DTI).
  • To explore GFV as a potential objective biomarker for MS motor dysfunction.

Main Methods:

  • GFV was measured during a grasping and lifting task in 27 MS patients and 23 controls using a force transducer grip device.
  • Clinical disability was assessed using the Expanded Disability Status Scale (EDSS) by experienced neurologists.
  • Diffusion tensor imaging (DTI) at 3T was used to measure fractional anisotropy (FA) in cerebral white matter.

Main Results:

  • GFV was significantly increased in MS patients compared to controls.
  • Increased GFV correlated with reduced fractional anisotropy (FA) in white matter near the somatosensory and visual cortex.
  • GFV also showed a significant correlation with the EDSS scores.

Conclusions:

  • GFV is an objective measure of motor dysfunction in MS.
  • GFV is linked to both clinical disability (EDSS) and underlying white matter microstructural changes.
  • GFV warrants further investigation as a supplementary tool to the EDSS in MS clinical trials, particularly in proof-of-concept studies.