Related Experiment Video
Updated: May 19, 2026
08:03
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Non-syndromic oxycephaly and brachycephaly: a review
Matthieu Vinchon1, Philippe Pellerin, Marc Baroncini
1Department of Pediatric Neurosurgery, Lille University Hospital, Lille, France. matthieu.vinchon@chru-lille.fr
Summary
Non-syndromic coronal synostoses oxycephaly and brachycephaly (NSCSOB) present a high risk of intracranial hypertension and developmental issues. Early diagnosis and prolonged follow-up are crucial for managing these rare conditions.
Area of Science:
- Craniofacial Surgery
- Pediatric Neurosurgery
- Medical Genetics
Background:
- Non-syndromic coronal synostoses oxycephaly and brachycephaly (NSCSOB) are rare congenital skull malformations.
- The natural history, surgical interventions, and outcomes for NSCSOB remain subjects of ongoing debate.
- Understanding NSCSOB is critical due to potential risks of intracranial hypertension and developmental compromise.
Purpose of the Study:
- To review the existing literature on NSCSOB.
- To retrospectively analyze the experience of a joint craniofacial team in managing NSCSOB cases since 1984.
- To elucidate the presentation, management strategies, and long-term outcomes of NSCSOB.
Main Methods:
- Comprehensive literature review on NSCSOB.
- Retrospective analysis of NSCSOB cases managed by a specialized craniofacial team.
- Surgical interventions included perifrontal craniectomy for newborns and fronto-orbital advancement with frontoparietal remodeling for older children.
Main Results:
- NSCSOB cases exhibit varied presentations, from prenatal onset with dysmorphism to later-life intracranial volume restriction.
- Of 61 treated cases, 19.7% evolved from initial unisutural synostoses.
- Initial intracranial hypertension was noted in 45.9% of patients, with significant rates of ophthalmological consequences (21.3%) and mental retardation (9.6%).
Conclusions:
- NSCSOB represents a complex condition characterized by a high risk of intracranial hypertension and potential hydrodynamic complications.
- Genetic screening is essential for confirming the non-syndromic nature of these conditions.
- Continuous monitoring of craniosynostosis cases is vital, as unisutural synostoses can progress to NSCSOB, and NSCSOB can evolve into more complex craniofaciosynostosis.
More Related Videos
Related Concept Videos
01:22Sutures of the Skull
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
01:08Overview of the Skull
The cranium (skull) is the skeletal structure of the head that supports the face and protects the brain. It is subdivided into the facial bones and the brain case, or cranial vault. The facial bones underlie the facial structures, form the nasal cavity, enclose the eyeballs, and support the teeth of the upper and lower jaws.
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
01:14Cranial Bones: Superior and Posterior View
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...