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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Related Experiment Video

Updated: May 19, 2026

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
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Published on: May 2, 2012

Molecular imaging in atherosclerosis: FDG PET.

David Rosenbaum1, Antoine Millon, Zahi A Fayad

  • 1Unité de Prévention Cardiovasculaire, Pole Cardiologie Métabolisme, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 83, Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. david.rosenbaum@psl.aphp.fr

Current Atherosclerosis Reports
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Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) offers noninvasive inflammation imaging. While promising for monitoring therapies and assessing vascular diseases, standardization and event-driven studies are needed for clinical use.

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Area of Science:

  • Nuclear Medicine
  • Molecular Imaging
  • Vascular Biology

Background:

  • 18F-FDG PET is a noninvasive tool for functional imaging of inflammation.
  • Low spatial resolution is overcome by coregistration with CT or MRI.
  • Mechanistic insights link signals to hypoxia, macrophage infiltration, and differentiation.

Purpose of the Study:

  • To review the current applications and limitations of 18F-FDG PET in inflammation imaging.
  • To discuss recent advancements in understanding vascular inflammation and its assessment.
  • To evaluate the potential of 18F-FDG PET in monitoring therapeutic responses.

Main Methods:

  • Review of current literature on 18F-FDG PET for inflammation imaging.
  • Analysis of studies investigating plaque anatomy, function, and inflammation in carotid arteries and aortic aneurysms.
  • Examination of 18F-FDG PET's role in monitoring therapies in animal and human studies.

Main Results:

  • 18F-FDG PET shows potential in linking vascular plaque characteristics with inflammation and clinical events.
  • Challenges remain in coronary artery imaging due to myocardial uptake, though developments are ongoing.
  • The technique has demonstrated ability to monitor inflammation before and after therapies.

Conclusions:

  • 18F-FDG PET is a valuable tool for inflammation imaging, with emerging applications in vascular diseases.
  • Further standardization and prospective, event-driven studies are crucial for its integration into clinical practice.
  • The technique holds promise for personalized therapy monitoring in inflammatory conditions.