Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of B_{c}^{+}→Dh^{+}h^{-} Decays.

Physical review letters·2026
Same author

First Observation of the Charmless Baryonic Decay B^{+}→Λ[over ¯]pp[over ¯]p.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of Orbitally Excited B_{c}^{+} States.

Physical review letters·2025
Same author

Measurement of the Z-Boson Mass.

Physical review letters·2025
Same author

Observation of a New Charmed Baryon Decaying to Ξ_{c}^{+}π^{-}π^{+}.

Physical review letters·2025
Same journal

Effect of muscle atrophy on fracture healing: insights from a tibial musculoskeletal-finite element model.

Biomechanics and modeling in mechanobiology·2026
Same journal

A multi-fidelity poroelastic finite element and machine learning framework for characterizing respiratory mechanics in porcine lungs.

Biomechanics and modeling in mechanobiology·2026
Same journal

Mechanics and mechanobiology of arterial development.

Biomechanics and modeling in mechanobiology·2026
Same journal

Mechanics-driven emergence of mesenchymal migration features.

Biomechanics and modeling in mechanobiology·2026
Same journal

Parameter estimation in blood flow models from highly undersampled k-space magnetic resonance imaging data.

Biomechanics and modeling in mechanobiology·2026
Same journal

Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis.

Biomechanics and modeling in mechanobiology·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

Linking continuous and discrete intervertebral disc models through homogenisation.

N Karajan1, O Röhrle, W Ehlers

  • 1Institute of Applied Mechanics (Civil Engineering), University of Stuttgart, Pfaffenwaldring 7, 70569, Stuttgart, Germany. karajan@mechbau.uni-stuttgart.de

Biomechanics and Modeling in Mechanobiology
|August 9, 2012
PubMed
Summary
This summary is machine-generated.

This study presents a novel method to couple finite-element method (FEM) and multi-body systems (MBS) for simulating spine mechanics. This approach enhances accuracy by using FEM for intervertebral discs (IVDs) within an MBS framework, avoiding complex co-simulation algorithms.

More Related Videos

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

Related Experiment Videos

Last Updated: May 19, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

Area of Science:

  • Biomechanics
  • Computational Mechanics
  • Spine Mechanics

Background:

  • Two primary numerical methods, finite-element method (FEM) and multi-body systems (MBS), are used to simulate human spine mechanics.
  • FEM models biological tissues at a macroscopic level, while MBS models bones as rigid bodies connected by muscle and connective tissue analogues.

Purpose of the Study:

  • To present a novel approach for coupling FEM and MBS for spine simulations.
  • To enhance the accuracy of multi-body dynamics models by incorporating homogenized finite-element results for intervertebral discs (IVDs).
  • To avoid the need for complex gluing algorithms in co-simulation by using pre-computed offline data.

Main Methods:

  • Coupling FEM and MBS by pre-computing the behavior of the intervertebral disc (IVD) using FEM.
  • Applying the discrete degrees of freedom (DOF) from MBS to the FE model of the IVD.
  • Recording homogenized forces and moments from the FE model.
  • Developing a polynomial function to approximate the homogenized FE results based on MBS DOFs.

Main Results:

  • A method to couple FEM and MBS without requiring a gluing algorithm was successfully developed.
  • Pre-computation of IVD behavior allowed for the generation of an approximation of homogenized FE results.
  • A polynomial function was derived to represent the relationship between MBS DOFs and homogenized forces/moments.

Conclusions:

  • The proposed coupling approach offers a viable alternative for simulating spine mechanics with improved accuracy.
  • This method facilitates the integration of detailed FEM analysis into broader MBS simulations.
  • The offline pre-computation strategy simplifies the co-simulation process for biomechanical modeling of the spine.