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Redefining normal reference ranges for echocardiography: a major new individual person data meta-analysis

Katrina K Poppe1, Robert N Doughty, Gillian A Whalley

  • 1Department of Medicine, The University of Auckland, Park Road, Private Bag 92019, Auckland 1142, New Zealand. k.poppe@auckland.ac.nz

European Heart Journal. Cardiovascular Imaging
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...