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Updated: May 19, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
Published on: January 20, 2022
Predicting compensation voltage for singly-charged ions in high-field asymmetric waveform ion mobility spectrometry
Alexander A Aksenov1, James Kapron, Cristina E Davis
1LGC Ltd, Teddington, Middlesex, UK. aaaksenov@ucdavis.edu
Abstract:
Correlation between compensation voltage (CV) and the m/z ratio of singly-charged ions was elucidated. The experimental data for various alkylammonium homologues and various pharmaceutical compounds were used to construct empirical calibration curves that were fit using commercial regression analysis software packages. The best fit equations were applied to calculate the CV differences (ΔCV) in pure N(2) and N(2)/He 50/50 carrier gasses and CV values for a variety of compounds using only m/z values. The calculated values were in good agreement with experimental data and ΔCV values exhibited a very strong correlation with m/z. Application of these empirical calculations may provide a powerful CV prediction tool for researchers using high-field asymmetric waveform ion mobility spectrometry (FAIMS) and increase the value of FAIMS as an analytical method.
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