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The diagnostic value of treadmill exercise test parameters for coronary artery disease

Jian Ling Sun1, Rong Han, Ji Hong Guo

  • 1Department of Cardiology, Aviation General Hospital, An Ding Men Wai Bei Yuan Road 3, Beijing 100012, China, sunjianling2000@yahoo.com.cn

Cell Biochemistry and Biophysics
|August 9, 2012
PubMed

Insights

The treadmill exercise test (TET) shows significant diagnostic value for coronary heart disease (CHD), especially in multi-vessel disease cases. This noninvasive method aids in identifying CHD, with results comparable to coronary angiography (CAG).

Area of Science:

  • Cardiology
  • Diagnostic Imaging
  • Clinical Medicine

Background:

  • Coronary heart disease (CHD) diagnosis relies on invasive procedures like coronary angiography (CAG).
  • Noninvasive diagnostic tools are crucial for early and accessible CHD detection.
  • The diagnostic accuracy of the treadmill exercise test (TET) for CHD requires further evaluation against CAG.

Purpose of the Study:

  • To assess the diagnostic efficacy of the treadmill exercise test (TET) in identifying coronary heart disease (CHD).
  • To compare the diagnostic conclusions of TET with the gold standard coronary angiography (CAG).
  • To evaluate TET's performance in patients with single-vessel versus multi-vessel coronary artery disease.

Main Methods:

  • A cohort of 445 patients with suspected or confirmed CHD underwent both TET and CAG.
  • Diagnostic outcomes from TET were compared against CAG results to determine sensitivity, specificity, and predictive values.
  • Analysis included patient parameters like exercise duration, heart rate, and ST-segment changes in relation to CAG findings.

Main Results:

  • TET demonstrated a sensitivity of 79.36% and specificity of 80.40% for CHD diagnosis.
  • The positive predictive value was 75.00%, and the negative predictive value was 84.08%.
  • Patients with multi-vessel disease showed a higher positive TET rate compared to those with single-vessel disease (P < 0.05).
  • Key exercise parameters differed significantly between CHD positive and negative groups, with lower exercise time and higher ST depression extent/duration in CHD positive patients.

Conclusions:

  • The treadmill exercise test (TET) is a valuable noninvasive tool for diagnosing coronary heart disease (CHD).
  • TET exhibits good diagnostic accuracy, comparable to coronary angiography (CAG) in certain patient groups.
  • The test is particularly effective for identifying CHD in patients with multi-vessel disease.

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