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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

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Related Experiment Video

Updated: May 19, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

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Published on: January 18, 2019

Immunotactoid glomerulopathy: clinicopathologic and proteomic study.

Samih H Nasr1, Mary E Fidler, Lynn D Cornell

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. nasr.samih@mayo.edu

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|August 9, 2012
PubMed
Summary
This summary is machine-generated.

Immunotactoid glomerulopathy (ITG) is a rare kidney disease. This study reveals ITG often associates with hematologic malignancy and has a better prognosis than similar conditions, with a favorable proteomic profile.

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Area of Science:

  • Nephrology
  • Pathology
  • Immunology

Background:

  • Immunotactoid glomerulopathy (ITG) is a rare glomerular disease.
  • This study presents the largest clinicopathologic series of ITG to date.
  • The proteomic profile of ITG was defined.

Purpose of the Study:

  • To describe the clinicopathologic features of ITG.
  • To define the proteomic profile of ITG.
  • To evaluate the prognosis of ITG.

Main Methods:

  • Retrospective analysis of 16 ITG patients from 1993-2011.
  • Laser microdissection and mass spectrometry (LMD/MS) performed on three cases.
  • Clinicopathologic data and proteomic analysis were utilized.

Main Results:

  • Patients presented with proteinuria (100%), nephrotic syndrome (69%), renal insufficiency (50%), and microhematuria (80%).
  • Hematologic malignancy was found in 38% of patients, including various lymphomas and myeloma.
  • Proteomic analysis revealed immunoglobulin light chains, complement factors, and serum amyloid P-component.

Conclusions:

  • Hematologic malignancy, especially lymphoma, is a significant comorbidity in ITG.
  • ITG demonstrates a better prognosis compared to other paraprotein-related renal diseases, with potential for recovery.
  • The proteomic signature of ITG indicates monotypic immunoglobulin deposition and complement pathway activation.