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Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
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Published on: January 8, 2018

Regulation of the androgen receptor by post-translational modifications

Kelly Coffey1, Craig N Robson

  • 1Solid Tumour Target Discovery Group, The Medical School, Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, Tyne and Wear, UK.

The Journal of Endocrinology
|August 9, 2012
PubMed

Insights

This review explores how modifying the androgen receptor (AR) through processes like phosphorylation and acetylation impacts prostate cancer and Kennedy

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Cancer Research

Background:

  • The androgen receptor (AR) is crucial in prostate cancer and Kennedy's disease.
  • Understanding AR regulation is vital for developing new therapies.

Purpose of the Study:

  • To review the post-translational modifications of the androgen receptor.
  • To focus on the interplay between these modifications and their functional consequences.

Main Methods:

  • Literature review of post-translational modifications of the androgen receptor.
  • Analysis of functional interactions between different modifications.

Main Results:

  • Post-translational modifications (phosphorylation, acetylation, sumoylation, ubiquitination, methylation) regulate AR.
  • These modifications interact functionally within signaling pathways.

Conclusions:

  • Interplay between AR modifications is critical for its function.
  • Understanding these complex interactions can guide therapeutic strategies for AR-related diseases.

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