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Alzheimer Disease l: Introduction

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Alzheimer's Disease: Overview

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Biological Effects of Radiation

Biological Effects of Radiation

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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue·2011

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Related Experiment Video

Updated: May 19, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Does ionizing radiation influence Alzheimer's disease risk?

Nasrin Begum¹, Bing Wang, Masahiko Mori

¹Center for Nuclear Medicine and Ultrasound, Rajshahi Medical College Hospital Campus, GPO Box No. 35, Rajshahi, Bangladesh.

Journal of Radiation Research

|August 9, 2012

Summary

Ionizing radiation exposure may increase Alzheimer's disease risk. This review explores the link between radiation, brain aging, and Alzheimer's pathogenesis for better understanding and prevention strategies.

Related Experiment Videos

Last Updated: May 19, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Area of Science:

Neuroscience
Radiology
Gerontology

Background:

Alzheimer's disease (AD) is a growing global health concern, particularly with aging populations.
Emerging evidence suggests ionizing radiation (IR) may influence brain health and potentially AD development.
Understanding the interplay between IR exposure and AD pathogenesis is crucial.

Purpose of the Study:

To review current research on the biological and cognitive effects of IR on the brain.
To investigate the impact of IR on brain aging processes relevant to AD.
To explore potential connections between IR exposure and Alzheimer's disease.

Main Methods:

Literature review of recent studies on IR effects in the brain.
Analysis of research on IR and cognitive function.
Examination of studies linking IR exposure to aging and neurodegeneration.

Main Results:

IR can induce biological and cognitive changes in the brain.
Evidence suggests IR exposure may accelerate brain aging.
Potential mechanisms linking IR to AD pathogenesis are being identified.

Conclusions:

IR exposure is a potential risk factor for Alzheimer's disease.
Further research is needed to elucidate the precise mechanisms.
Understanding these links is vital for future preventative measures against AD.