Related Experiment Video
Updated: May 19, 2026
External Cephalic Version: Is it an Effective and Safe Procedure?
Published on: June 6, 2020
Effect of antenatal tocolysis on neonatal outcomes
Chad K Klauser1, Christian M Briery, Sharon D Keiser
1Department of Obstetrics and Gynecology, The Mount Sinai Medical Center, New York City, NY, USA.
Objective:
Detail adverse neonatal effects in pregnancies treated with indomethacin (I), magnesium sulfate (M) or nifedipine (N).
Methods:
Women in acute preterm labor with cervical dilatation 1-6 cm were randomized to receive one of three first-line tocolytic drugs.
Results:
There were 317 neonates (I = 103, M = 95, N = 119) whose mothers were treated with tocolytic therapy. There was no difference in gestational age at randomization (average 28.6 weeks' gestation) or at delivery (31.6 weeks' gestation, p = 0.551), birth weight (p = 0.871) or ventilator days (p = 0.089) between the three groups. Neonatal morbidity was not different between the three groups; respiratory distress syndrome (p = 0.086), patent ductus arteriosus (p = 0.592), sepsis (p = 0.590), necrotizing enterocolitis (p = 0.770), intraventricular hemorrhage (p = 0.669) and periventricular leukomalacia (p = 0.124).
Conclusions:
There were no statistically significant differences between the three tocolytics as far as composite neonatal morbidity or mortality was concerned.
