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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Updated: May 19, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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The landscape for epigenetic/epigenomic biomedical resources.

Kabita Shakya1, Mary J O'Connell, Heather J Ruskin

  • 1Centre for Scientific Computing & Complex Systems Modelling (SCI-SYM), School of Computing, Dublin City University, Dublin, Ireland. kabita.shakya@gmail.com

Epigenetics
|August 10, 2012
PubMed
Summary

Bioinformatics has advanced biomedical research, necessitating better data storage and access. This paper reviews available resources, focusing on epigenetics/epigenomics data mining and analysis tools.

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Last Updated: May 19, 2026

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Area of Science:

  • Biomedical research
  • Bioinformatics
  • Computational biology

Background:

  • Molecular biology and computational power advances drive the biomedical sector.
  • Massive data generation necessitates advanced storage and public repositories.
  • Increasing biomedical resources present data mining challenges.

Purpose of the Study:

  • Provide an overview of current biomedical data resources.
  • Discuss data mining and analysis capabilities of these resources.
  • Focus on resources supporting the shift towards epigenetics/epigenomics research.

Main Methods:

  • General review of available biomedical data resources.
  • Analysis of data mining and analysis capabilities.
  • Consideration of both text and numerical data mining techniques.
  • Emphasis on resources relevant to epigenetics/epigenomics.

Main Results:

  • Identified a growing number of biomedical resources.
  • Highlighted challenges in mining large, diverse datasets.
  • Noted the emergence of resources for epigenetics/epigenomics research.
  • Considered text mining (automated analysis, information extraction) and numerical data mining (pattern recognition, prediction).

Conclusions:

  • The landscape of biomedical data resources is expanding rapidly.
  • Effective data mining and analysis are crucial for leveraging these resources.
  • Specialized resources are increasingly available to support epigenetics/epigenomics research.
  • This review offers a guideline for assessing and comparing relevant resources.