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Related Experiment Video

Updated: May 19, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Promoting generic medication prescribing by order interface redesign: small change, large impact.

Sameer Malhotra¹, Jessica S Ancker, J Travis Gossey

¹Weill Medical College, Cornell University, New York, NY, USA. sam2032@med.cornell.edu

Studies in Health Technology and Informatics

|August 10, 2012

Summary

Redesigning electronic health records to favor generic medications significantly boosted their prescription rates by 36.9%. This intervention streamlined the process, encouraging the use of cost-effective generic drugs.

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

Improving IV Insulin Administration in a Community Hospital

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Published on: June 11, 2012

Area of Science:

Health Informatics
Pharmacoeconomics
Clinical Pharmacy

Background:

Rising healthcare expenditures are significantly influenced by prescription drug costs.
Electronic health records (EHRs) offer potential for optimizing prescribing patterns.
Generic medications present a cost-saving alternative to brand-name drugs.

Purpose of the Study:

To evaluate the impact of an EHR interface redesign on generic medication prescribing behavior.
To assess the effectiveness of automated generic substitution prompts in clinical practice.

Main Methods:

A before-and-after retrospective study was conducted.
The EHR order entry interface was modified to automatically substitute brand medications with generic equivalents.
Clinicians were required to actively select "dispense as written" to override the generic suggestion.

Main Results:

A net increase of 36.9% in generic medication prescriptions was observed post-redesign.
The interface change successfully shifted prescribing behavior towards generic options.
The "dispense as written" override was used minimally, indicating high acceptance of generic suggestions.

Conclusions:

Redesigning EHR interfaces can be an effective strategy to increase generic prescribing rates.
Automated prompts and simplified workflows can promote cost-effective medication choices.
This approach has the potential to reduce overall healthcare costs associated with prescription drugs.