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Related Experiment Video

Updated: May 19, 2026

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
16:38

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

ATP derived from astrocytes modulates memory in the chick.

Marie E Gibbs1, Maria Shleper, Tomris Mustafa

  • 1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. marie.gibbs@monash.edu

Neuron Glia Biology
|August 10, 2012
PubMed
Summary
This summary is machine-generated.

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Endogenous adenosine triphosphate (ATP) modulates memory consolidation in chicks via P2Y1 receptors. Astrocytes release ATP, influencing neuronal activity and calcium signaling essential for memory formation.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Memory consolidation involves transitions from short- to long-term storage.
  • Adenosine triphosphate (ATP) and purinergic receptors are implicated in hippocampal function.
  • Astrocytes play crucial roles in neuronal signaling and support.

Purpose of the Study:

  • To investigate the role of endogenous ATP in memory consolidation in a chick model.
  • To identify the specific purinergic receptors involved in memory consolidation.
  • To explore the contribution of astrocytes to ATP-mediated memory processes.

Main Methods:

  • Utilized a discriminative bead pecking task for memory assessment.
  • Administered purinergic receptor antagonists (PPADS, MRS2179) and agonists (ATPγS, ADPβS).

More Related Videos

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

Related Experiment Videos

Last Updated: May 19, 2026

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
16:38

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

Isolation and Culture of Mouse Cortical Astrocytes
11:25

Isolation and Culture of Mouse Cortical Astrocytes

Published on: January 19, 2013

  • Measured intracellular calcium ([Ca2+]i) in astrocytes and assessed effects of metabolic inhibitors.

    • Main Results:

    • Non-selective and P2Y1-specific antagonists blocked memory consolidation.
    • ATP agonists potentiated memory consolidation, with ADPβS effects blocked by MRS2179.
    • Astrocytic [Ca2+]i increased with ATP agonists, mediated by P2Y1 receptors and oxidative metabolism.

    Conclusions:

    • Endogenous ATP acting via astrocytic P2Y1 receptors is critical for memory consolidation.
    • Astrocytes release ATP during learning, modulating neuronal activity and calcium signaling.
    • Astrocytic calcium signaling is essential for the transition of memory to long-term storage.