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MR imaging in a patient with Leigh's disease (subacute necrotizing encephalomyelopathy)
S V Manzi1, K H Hager, F R Murtagh
1Department of Radiology, University of South Florida, College of Medicine, Tampa.
Abstract:
Leigh's disease, also known as subacute necrotizing encephalomyelopathy, is a rare progressive neurological disorder of childhood that was first described by Leigh in 1951. Diagnosis of this disease can be difficult because onset is usually insidious and can present with a number of different focal findings, however diagnostic imaging has been shown to be of benefit in this regard. We present a patient with Leigh's disease in whom serial MR imaging studies helped to make the diagnosis and also demonstrated the dynamic characteristic of this disease process.
Insights
Leigh's disease, a rare neurological disorder, is challenging to diagnose due to its insidious onset. Serial MRI studies proved beneficial in diagnosing this condition and observing its dynamic nature.
Area of Science:
- Neurology
- Pediatric Neurology
- Neuroimaging
Background:
- Leigh's disease, or subacute necrotizing encephalomyelopathy, is a rare, progressive neurological disorder affecting children.
- Diagnosis can be challenging due to insidious onset and varied focal findings.
Observation:
- This case report details a patient diagnosed with Leigh's disease.
- Serial magnetic resonance (MR) imaging studies were utilized for diagnosis.
Findings:
- Diagnostic imaging, specifically serial MR imaging, aided in the diagnosis of Leigh's disease.
- The imaging studies revealed the dynamic characteristics of the disease process.
Implications:
- Serial MR imaging is a valuable tool for diagnosing Leigh's disease.
- Understanding the dynamic nature of Leigh's disease through imaging can inform patient management and prognosis.