Related Experiment Video
Updated: May 19, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Association study of NOS1 gene polymorphisms and schizophrenia]
Jia Wang1, Xiao-hong Ma, Bo Xiang
1Sichuan University, Chengdu, Sichuan, People's Republic of China.
Objective:
To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia.
Methods:
Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.
Results:
One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease.
Conclusion:
Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
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