Related Experiment Video
Updated: May 19, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
[Intracellular signaling transduction pathways. Potential targets in the treatment of rheumatic diseases]
K W Frommer1, M Geyer, G S Firestein
1Innere Medizin mit Schwerpunkt Rheumatologie, Kerckhoff-Klinik, Abt. Rheumatologie und Klin. Immunologie, Franz-Groedel-Institut, Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland. k.frommer@kerckhoff-klinik.de
Abstract:
Even though biologics, frequently combined with conventional DMARD therapy, represent a significant advance in the treatment of rheumatic diseases, they have disadvantages such as high costs of production and parenteral administration. Therefore, oral small-molecule drugs are a potential alternative. Major targets for such small-molecule therapeutics are intracellular signaling molecules. This article will briefly discuss potential intracellular targets for therapeutics in the field of rheumatic diseases. How therapeutic signaling inhibitors will be used in clinical practice will depend on a number of factors: their overall effectiveness, their effectiveness in patients who did not or insufficiently respond to conventional DMARD therapy and/or treatment with biologics, their effectiveness when combined with other therapeutics, their side effects, and their cost-benefit ratio.The English full-text version of this article is available at SpringerLink (under "Supplemental").
Related Concept Videos
The JAK-STAT Signaling Pathway
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease III: Medical Management
Signal Transduction: Overview
Typically, signal transduction involves three...