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Updated: May 19, 2026

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
Published on: September 28, 2017
Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP
Matthieu P M H Benoit1, Michael J Plevin
1Institut de Biologie Structurale Jean-Pierre Ebel, CEA, 41, rue Jules Horowitz, 38027 Grenoble, France.
Abstract:
TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.
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