Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Table tennis and cognitive skills: A study on attention and decision making in sports science students.

PloS one·2026
Same author

Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study.

European journal of pediatrics·2026
Same author

Prof. Dr. Enver Hasanoğlu (1946-2026).

The Turkish journal of pediatrics·2026
Same author

Xq27.3-q28 duplication involving the <i>FMR1</i> gene presenting with familial X-linked hypogonadism, gynecomastia, short stature, intellectual disability, and obesity syndrome: a case report and review of the literature.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same author

Impact of SARS-CoV-2 Infection on Diabetic Ketoacidosis in Children with Newly Diagnosed Type-1 Diabetes: A Prospective Multicenter Study.

Medeniyet medical journal·2026
Same author

Nail Disorders in Children With Down Syndrome: A Multicenter Study.

Pediatric dermatology·2026

Related Experiment Video

Updated: May 19, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin D status in children with Hashimoto thyroiditis.

Orhun M Camurdan1, Esra Döğer, Aysun Bideci

  • 1Department of Pediatric Endocrinology, School of Medicine, Gazi University, Ankara, Turkey. turkalpo@yahoo.com

Journal of Pediatric Endocrinology & Metabolism : JPEM
|August 11, 2012
PubMed
Summary

Children with Hashimoto thyroiditis have significantly higher rates of vitamin D deficiency. Lower vitamin D levels in these children may play a role in the autoimmune process of this condition.

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Related Experiment Videos

Last Updated: May 19, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Area of Science:

  • Pediatric Endocrinology
  • Immunology
  • Nutritional Science

Background:

  • Hashimoto thyroiditis is a common autoimmune disorder affecting children.
  • Vitamin D plays a crucial role in immune system regulation.
  • The relationship between vitamin D status and Hashimoto thyroiditis in pediatric populations requires further investigation.

Purpose of the Study:

  • To assess vitamin D status in children diagnosed with Hashimoto thyroiditis.
  • To compare vitamin D levels between children with Hashimoto thyroiditis and healthy controls.
  • To explore the correlation between vitamin D levels and thyroid autoimmunity markers.

Main Methods:

  • A case-control study involving 78 children with newly diagnosed Hashimoto thyroiditis and 74 healthy controls.
  • Measurement of calcium metabolism parameters, thyroid function tests, and 25-hydroxyvitamin D [25(OH)D] levels.
  • Statistical analysis to compare groups and assess correlations.

Main Results:

  • Vitamin D deficiency was significantly more prevalent in children with Hashimoto thyroiditis (73.1%) compared to controls (17.6%).
  • Mean 25(OH)D levels were substantially lower in the Hashimoto group (31.2 nmol/L) versus the control group (57.9 nmol/L).
  • A significant inverse correlation was observed between 25(OH)D levels and anti-thyroid peroxidase (anti-TPO) antibodies (r = -0.30, p = 0.007).

Conclusions:

  • Children with Hashimoto thyroiditis exhibit higher rates of vitamin D deficiency and lower circulating vitamin D levels.
  • The findings suggest a potential role for vitamin D deficiency in the pathogenesis of autoimmune thyroid disease in children.
  • Further research is warranted to explore vitamin D supplementation as a therapeutic strategy for pediatric Hashimoto thyroiditis.