Related Experiment Video

Updated: May 19, 2026

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
05:30

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

Published on: October 31, 2025

[Gastrinoma has an infrequent prevalence in pediatric age: a case report]

Guilherme Endrigo Fernandes1, Tatiana Larissa Medeiros Arcanjo, Nubia Mendonça

  • 1Universidade Federal da Bahia, Salvador, Bahia, Brasil. endrigo.gui@hotmail.com

Acta Gastroenterologica Latinoamericana
|August 11, 2012
PubMed

Insights

This study details a rare pediatric gastrinoma case in a toddler. Elevated serum gastrin and endoscopic findings confirmed the diagnosis, highlighting the need to consider this rare tumor in children.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Oncology

Background:

  • Gastrinoma, a rare neuroendocrine tumor, primarily affects young adults.
  • Diagnosis typically involves elevated serum gastrin levels and characteristic endoscopic findings.
  • Consideration in pediatric populations is infrequent but crucial when symptoms align.

Observation:

  • A case study of a 1-year, 9-month-old patient presenting with clinical, laboratory, and radiological signs of gastrinoma.
  • Fasting laboratory tests revealed significantly elevated serum gastrin levels.
  • Endoscopic examination identified an elevated lesion with central depression.

Findings:

  • Immunohistochemical analysis confirmed the tumor's benign nature.
  • Evidence of hyperplasia of argentaffin cells was noted.
  • The findings support a diagnosis of gastrinoma in a pediatric patient.

Implications:

  • This case underscores the importance of considering gastrinoma in pediatric patients with suggestive clinical and laboratory findings.
  • Early diagnosis and management are critical for rare pediatric tumors.
  • Highlights the need for expanded differential diagnoses in pediatric endocrinology and oncology.

Related Concept Videos

Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...