Related Experiment Video
Updated: May 19, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Public vaccination policy using an age-structured model of pneumococcal infection dynamics
Karyn L Sutton1, H T Banks, Carlos Castillo-Chavez
1Center for Research in Scientific Computation, & Center for Quantitative Studies in Biomedicine, North Carolina State University, Raleigh, NC 27695-8212, USA. klsutton@ncsu.edu
Abstract:
Public health professionals are charged with the task of designing prevention programs for the effective control of biologically intricate infectious diseases at a population level. The effective vaccination of a population for pneumococcal diseases (infections caused by Streptococcus pneumoniae) remains a relevant question in the scientific community. It is complicated by heterogeneity in individuals' responses to exposure to the bacterium and their responses to vaccination. Due to these complexities, most modelling efforts in this area have been on the cellular/bacteria level. Here, we introduce an age-structured SEIS-type model of pneumococcal diseases and their vaccination. We discuss the use of this framework in predicting the impact of vaccine strategies, with pneumococcal diseases as an example. Using parameter values reasonable for a developed country, we discuss the effects of targeting the colonization and/or infection stages on the age profiles of morbidity in a population.
More Related Videos
Related Concept Videos
Vaccinations
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Vaccines
Pneumonia II: Pathophysiology
Modeling with Differential Equations
Pneumonia I: Introduction

