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Updated: May 19, 2026
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
Anabolic therapies for osteoporosis
Alexander V Uihlein1, Benjamin Z Leder
1Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Thier 1051, Boston, MA 02114, USA.
Endocrinology and Metabolism Clinics of North America
|August 11, 2012
Summary
Teriparatide is an effective osteoporosis treatment for high-fracture-risk patients. Following treatment, antiresorptive agents are crucial to maintain bone density and prevent bone loss.
Area of Science:
- Endocrinology
- Bone Metabolism
- Pharmacology
Background:
- Teriparatide is the first FDA-approved anabolic agent for osteoporosis.
- It is effective for patients at high risk of fracture.
- Limitations include cost, delivery method, and treatment duration.
Purpose of the Study:
- To review the efficacy and optimal use of teriparatide in osteoporosis management.
- To evaluate combination therapy with antiresorptive agents.
- To determine the role of antiresorptive therapy post-teriparatide.
Main Methods:
- Review of available data on teriparatide therapy.
- Analysis of studies on combination therapy with antiresorptive agents.
- Evaluation of post-teriparatide treatment strategies.
Main Results:
- Combination therapy with teriparatide and antiresorptives shows no added therapeutic benefit.
- Antiresorptive therapy after teriparatide is essential to prevent bone loss.
- Prior bisphosphonate use does not preclude successful teriparatide treatment, though it may slightly reduce its anabolic effect.
Conclusions:
- Teriparatide is a valuable anabolic therapy for high-risk osteoporosis patients.
- Sequential therapy with antiresorptives post-teriparatide is critical for sustained bone density.
- Clinicians should consider teriparatide even in patients with prior bisphosphonate exposure.
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