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Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

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Related Experiment Video

Updated: May 19, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

How vitamin D works on bone.

Tomohiko Yoshida1, Paula H Stern

  • 1Division of Endocrinology, Diabetes and Metabolism, Chiba University Hospital, 1-8-1 Inohana, Chiba-shi, Chiba 260-8670, Japan.

Endocrinology and Metabolism Clinics of North America
|August 11, 2012
PubMed
Summary
This summary is machine-generated.

Vitamin D is crucial for bone health, aiding mineralization and calcium absorption. Despite in vitro resorption effects, in vivo use prevents bone loss and fractures, with analogues offering therapeutic benefits.

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Bone Biology

Background:

  • Vitamin D is essential for bone development and maintenance.
  • Understanding vitamin D's activation pathway and receptor has improved knowledge of its skeletal actions.
  • The active form, 1,25(OH)₂D₃, is key to these processes.

Purpose of the Study:

  • To review the role of vitamin D in bone health.
  • To discuss the mechanisms by which vitamin D influences bone mineralization and resorption.
  • To highlight the therapeutic potential of vitamin D and its analogues in preventing bone loss and fractures.

Main Methods:

  • Literature review of studies on vitamin D metabolism and action.
  • Analysis of evidence regarding vitamin D's effects on calcium and phosphate absorption.
  • Examination of in vitro and in vivo studies on bone resorption and fracture prevention.

Main Results:

  • 1,25(OH)₂D₃ enhances bone mineralization by promoting calcium and phosphate absorption.
  • While 1,25(OH)₂D₃ can stimulate bone resorption in vitro, in vivo administration prevents bone loss.
  • Vitamin D analogues offer therapeutic strategies for improving bone mineral density and reducing fracture risk.

Conclusions:

  • Vitamin D plays a vital role in maintaining bone integrity.
  • The therapeutic application of vitamin D and its analogues is effective in managing bone loss and fractures.
  • Further research into vitamin D's mechanisms can lead to improved skeletal health treatments.