Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Werner's Syndrome].

T Kołodziej1, J Maj, M Ziarkiewicz

  • 1Kliniki Dermatologicznej AM we Wrocławiu.

Przeglad Dermatologiczny
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Werner's syndrome presents with characteristic aging symptoms like tissue atrophy, hair changes, skin lesions, osteoporosis, and hormonal imbalances. This rare genetic disorder significantly resembles natural aging processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of the impact of childhood psoriasis on mothers' and fathers' quality of life - does gender of a caregiver play a role?

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis.

BioMed research international·2019
Same author

Role of galectin-3 in subclinical myocardial impairment in psoriasis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

Methotrexate in the treatment of mycosis fungoides - a multicenter observational study in 79 patients.

European review for medical and pharmacological sciences·2018
Same author

Image Gallery: Cutaneous metastases from hidden carcinoma of the penis.

The British journal of dermatology·2017
Same author

Erratum to: The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat brain.

Psychopharmacology·2015
Same journal

[Mohs surgery--technique and indications].

Przeglad dermatologiczny·1990
Same journal

[Pathogenesis of systemic scleroderma--new evidence].

Przeglad dermatologiczny·1990
Same journal

[Enteropathic acrodermatitis in light of personal observations].

Przeglad dermatologiczny·1990
Same journal

[The usefulness of determining specific immunoglobulins E in atopic dermatitis in light of personal investigations].

Przeglad dermatologiczny·1990
Same journal

[IgE levels and hypersensitivity to certain inhaled and food allergens in acute and chronic urticaria].

Przeglad dermatologiczny·1990
Same journal

[Studies of natural killer cell cytotoxicity against human chondrocytes in patients with articular arthritic changes complicated by psoriasis and systemic scleroderma].

Przeglad dermatologiczny·1990
See all related articles

Area of Science:

  • Gerontology
  • Genetics
  • Internal Medicine

Background:

  • Werner's syndrome (WS) is a rare autosomal recessive disorder characterized by the premature onset of aging.
  • It affects multiple organ systems, leading to a wide range of clinical manifestations.

Observation:

  • The case presented exhibited all hallmark features of Werner's syndrome.
  • These included muscle and subcutaneous tissue atrophy, premature graying and thinning of hair, skin lesions (ulcers, hyperkeratosis), and widespread osteoporosis.
  • Ocular (bilateral cataracts), vocal (hoarse voice), dental (caries), endocrine (hormonal disturbances), and metabolic (abnormal glucose curve) abnormalities were also noted.

Findings:

  • The patient displayed a comprehensive set of symptoms consistent with Werner's syndrome.

Related Experiment Videos

  • A striking resemblance between the clinical presentation of Werner's syndrome and physiological senescence was observed.
  • Positive response to anabolic drug therapy was documented.

    • Implications:

    • Understanding Werner's syndrome provides insights into the mechanisms of aging.
    • Early diagnosis and management are crucial for addressing the multifaceted health issues in WS patients.
    • The response to anabolic drugs suggests potential therapeutic avenues for managing certain aspects of the syndrome.