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Updated: May 19, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
Published on: July 25, 2014
Introduction to genetic processes in transplantation
Teresa Santiago-Sim1, Sarah Colosimo, David J Powner
1University of Texas Medical School, Houston, TX, USA. teresa.santiagosim@uth.tmc.edu
Abstract:
Recent investigations have explored how analyses of genetic DNA from organ donors and recipients may be helpful during organ allocation so as to reduce graft rejection or improve dosing of immunosuppressive medications. This discussion reviews those data and the processes by which genetic coding controls the production of protein that is important in cellular structure and function during donor and recipient care. Changes in gene structure (polymorphisms or mutations) may occur spontaneously or as a result of cell interactions with environmental factors, and may be associated with recognized diseases or, potentially, could reduce or worsen graft rejection.
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