Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visible light reprograms MSCs and T cells into tumor-suppressive states via OPN4-mediated epigenetic remodeling.

Acta pharmacologica Sinica·2026
Same author

Correction: Xu et al. Nucleosome Clustering as a Biomarker and Mechanistic Switch for Reprogramming Cells. <i>Cells</i> 2026, <i>15</i>, 113.

Cells·2026
Same author

Preoperative Factors Associated With Postoperative Delirium in Older Patients With Cancer Undergoing Surgery: Retrospective Cohort Study.

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society·2026
Same author

Andean agriculture and hand tools: A qualitative approach of exploration of needs, barriers, and opportunities for innovation.

PloS one·2026
Same author

Induced Tumor-Suppressing (iTS) Cell-Based Approach for Protecting the Bone from Advanced Prostate Cancer.

Biomolecules·2026
Same author

Design of Gold Extraction Solvents Using Machine Learning Models.

ACS omega·2026
Same journal

Corrigendum to "The forgotten fat: A systematic review of mandibular adipose content in health and disease" [Bone 201 (2025) 117636].

Bone·2026
Same journal

Diagnosis and management of X-linked hypophosphatemia in dental practice: A scoping review.

Bone·2026
Same journal

Baseline β-CTX and BMI predict suitability for deferred zoledronic acid redosing beyond 12 months in postmenopausal Indian women with osteoporosis.

Bone·2026
Same journal

Bone density-based maturation of the midpalatal suture in children aged 8-15 years.

Bone·2026
Same journal

Disrupted phosphate metabolism and SIBLING/ASARM peptide accumulation underlie impaired bone mineralization in klotho-deficient (kl/kl) mice.

Bone·2026
Same journal

Linking genetic variants to bone microstructure: Histological signatures of osteogenesis imperfecta subtypes.

Bone·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee
05:04

A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee

Published on: July 5, 2021

Mechanical loading, damping, and load-driven bone formation in mouse tibiae.

Todd Dodge1, Mina Wanis, Ramez Ayoub

  • 1Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Bone
|August 11, 2012
PubMed
Summary
This summary is machine-generated.

Bone and joint tissues absorb mechanical loads, with joints providing the most damping. Bone curvature significantly enhances bone

More Related Videos

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

Related Experiment Videos

Last Updated: May 19, 2026

A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee
05:04

A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee

Published on: July 5, 2021

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

Area of Science:

  • Biomechanics
  • Skeletal Biology
  • Tissue Engineering

Background:

  • Mechanical loads are crucial for bone and joint health, influencing growth and remodeling.
  • While loading stimulates bone formation, damping mechanisms are vital for preventing injury.
  • Understanding how different tissues contribute to damping is essential for bone health research.

Purpose of the Study:

  • To investigate the damping capacity of bone, joint, muscle, and skin in a mouse hindlimb model.
  • To determine the contribution of bone curvature to mechanical damping.
  • To explore the relationship between mechanical loading, damping, and bone remodeling.

Main Methods:

  • Cyclic loading experiments on mouse hindlimb segments with progressively reduced surrounding tissues.
  • Finite element modeling to simulate bone curvature effects in silico.
  • Analysis of damping parameters: phase shift angle and energy loss.

Main Results:

  • The knee joint provided the largest damping capacity; bone accounted for approximately 38% of the phase shift.
  • Bone curvature enhanced damping capacity by about 40%, with increased effect at higher curvatures.
  • Bone formation was significantly enhanced in regions experiencing curvature-induced bending moments under loading.

Conclusions:

  • Damping of mechanical loads involves contributions from surrounding tissues and bone itself.
  • Naturally occurring bone curvature plays a significant role in enhancing bone's damping capacity.
  • These findings suggest a link between mechanical damping, bone curvature, and bone remodeling/quality.