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Related Concept Videos

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genetic Lingo01:11

Genetic Lingo

Overview
What is Behavior?00:54

What is Behavior?

Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...

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Related Experiment Video

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

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Published on: June 21, 2018

Candidate and non-candidate genes in behavior genetics.

Jonathan Flint1, Marcus R Munafò

  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. jf@well.ox.ac.uk

Current Opinion in Neurobiology
|August 11, 2012
PubMed
Summary

Recent psychiatric genetics research uses whole genome approaches to identify disease susceptibility genes. Candidate gene studies, focusing on serotonin transporter, also remain important for brain imaging and gene-environment interaction research.

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Area of Science:

  • Psychiatric Genetics
  • Neuroscience
  • Genomics

Background:

  • Advances in whole genome approaches are identifying genetic variants linked to psychiatric disorders.
  • Candidate gene studies, particularly involving the serotonin transporter, remain prevalent in brain imaging and gene-environment interaction research.

Purpose of the Study:

  • To review recent developments in psychiatric genetics, highlighting the intersection of whole genome and candidate gene studies.
  • To discuss the impact of whole genome findings on single locus analyses.

Main Methods:

  • Review of current literature on psychiatric genetics.
  • Analysis of genome-wide association studies (GWAS) and exome sequencing.
  • Examination of candidate gene studies, including those focusing on the serotonin transporter.

Main Results:

  • Whole genome studies are nearing the identification of key genes and molecular variants for disease susceptibility.
  • Candidate gene approaches continue to be central to understanding brain imaging phenotypes and gene-environment interactions.
  • There is an intersection between whole genome and candidate gene studies, though integration is not always seamless.

Conclusions:

  • Psychiatric genetics is advancing through both broad genomic and focused candidate gene strategies.
  • Improved integration of whole genome data could enhance single locus analyses and gene-environment interaction studies.