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Updated: May 19, 2026
05:48
Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Amyloidosis in autoinflammatory syndromes
Laura Obici1, Giampaolo Merlini
1Amyloidosis Research and Treatment Centre, Biotechnology Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Italy.
Autoimmunity Reviews
|August 11, 2012
Summary
Early detection of AA amyloidosis is crucial for patients with autoinflammatory diseases to prevent severe kidney damage and organ failure. Prompt treatment of the underlying inflammation is key to halting disease progression.
Area of Science:
- Rheumatology
- Nephrology
- Internal Medicine
Background:
- AA amyloidosis significantly impacts autoinflammatory disease patient outcomes, especially with delayed diagnosis.
- Early signs often manifest as kidney damage, including proteinuria and potential renal failure.
- Untreated SAA level elevation leads to end-stage kidney disease and dialysis.
Purpose of the Study:
- To emphasize the importance of early AA amyloidosis detection in autoinflammatory diseases.
- To highlight the clinical presentation and progression of AA amyloidosis.
- To discuss current and emerging therapeutic strategies.
Main Methods:
- Clinical observation and monitoring of patients with autoinflammatory diseases.
- Assessment of proteinuria, SAA concentration, and preclinical amyloid deposits.
- Review of therapeutic interventions, including anti-cytokine agents and renal transplantation.
Main Results:
- Delayed diagnosis of AA amyloidosis leads to severe complications and organ failure.
- Close monitoring for early red flags is essential for timely intervention.
- Effective control of inflammation can halt or reverse disease progression.
Conclusions:
- Maintaining vigilance for AA amyloidosis is critical for managing autoinflammatory diseases.
- Anti-cytokine therapies are vital for treating and preventing AA amyloidosis, especially in colchicine-resistant cases.
- Novel treatments targeting fibrillogenesis offer future therapeutic avenues.
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