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Related Experiment Video

Updated: May 19, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Adipose tissue inflammation and ectopic lipid accumulation.

Takayoshi Suganami¹, Miyako Tanaka, Yoshihiro Ogawa

¹Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Endocrine Journal

|August 11, 2012

Summary

Obesity drives chronic inflammation and insulin resistance through adipose tissue remodeling. Understanding these changes offers new therapeutic targets for metabolic diseases.

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Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

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Last Updated: May 19, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Localization, Identification, and Excision of Murine Adipose Depots

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Area of Science:

Metabolic disease research
Immunology
Cell biology

Background:

Obesity is a chronic inflammatory and metabolic disease.
Adipose tissue remodeling involves changes in adipocytes and stromal cells.
Inflammation and impaired lipid storage contribute to obesity-related complications.

Purpose of the Study:

Investigate the role of adipose tissue remodeling in obesity.
Elucidate mechanisms linking inflammation, insulin resistance, and lipid storage dysfunction.
Identify potential therapeutic targets for obesity.

Main Methods:

Analysis of adipose tissue cellular composition and function in obesity.
Investigation of paracrine signaling loops between adipocytes and immune cells.
Assessment of lipid storage capacity and inflammatory markers.

Main Results:

Obesity induces significant adipose tissue remodeling.
Macrophage infiltration and paracrine loops (e.g., saturated fatty acids, tumor necrosis factor-α) exacerbate inflammation.
Reduced lipid storage capacity contributes to ectopic lipid accumulation and lipotoxicity.

Conclusions:

Adipose tissue remodeling is a key driver of obesity-induced inflammation and insulin resistance.
Therapeutic strategies targeting adipose tissue inflammation and remodeling hold promise for treating obesity.