Related Experiment Video
Updated: May 19, 2026
09:57
Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
NCCN Clinical Practice Guidelines Acute myeloid leukemia.
Margaret R O'Donnell1, Camille N Abboud, Jessica Altman
1City of Hope Comprehensive Cancer Center, USA.
Journal of the National Comprehensive Cancer Network : JNCCN
|August 11, 2012
Summary
Acute myeloid leukemia (AML) is a common adult cancer. These guidelines offer comprehensive recommendations for AML diagnosis, risk stratification, and treatment strategies for adult patients.
Area of Science:
- Hematology
- Oncology
Background:
- Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults.
- AML contributes significantly to leukemia-related mortality in the United States.
Purpose of the Study:
- To present the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Acute Myeloid Leukemia (AML).
- To provide updated recommendations for the management of adult AML patients.
Main Methods:
- The guidelines cover diagnostic evaluation and workup for AML.
- Risk assessment incorporates cytogenetic and molecular features.
- Treatment recommendations address induction and consolidation therapies.
- Supportive care considerations are also detailed.
Main Results:
- The guidelines offer a structured approach to AML management.
- Recommendations are tailored for younger and older adult patients (age ≥ 65 years).
Conclusions:
- These NCCN Guidelines serve as a vital resource for clinicians managing adult AML.
- The guidelines emphasize a multidisciplinary approach integrating diagnostics, risk assessment, and tailored therapies.
Related Concept Videos
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:22Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
01:30National Nursing Organizations II
Nursing organizations play a vital role in representing nurses working in specialized clinical settings, such as the American Association of Critical-Care Nurses (AACN).
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...