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Colorectal cancer in inflammatory bowel diseases: CT features with pathological correlation
Lora Hristova1, Philippe Soyer, Christine Hoeffel
1Department of Abdominal Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 Rue Ambroise Paré, Paris, France. lora.hristova@lrb.aphp.fr
Abdominal Imaging
|August 11, 2012
Summary
Computed tomography (CT) shows two main patterns for colorectal cancer in inflammatory bowel disease (IBD). Type 2 tumors and free fluid on CT scans may indicate signet ring cells, aiding diagnosis.
Area of Science:
- Radiology
- Gastroenterology
- Oncology
Background:
- Inflammatory bowel disease (IBD) increases colorectal cancer risk.
- Accurate CT imaging is crucial for diagnosing IBD-related colorectal cancer.
- Distinguishing IBD-related colorectal cancer from chronic inflammation can be challenging.
Purpose of the Study:
- To characterize CT imaging features of colorectal cancer in patients with IBD.
- To correlate CT findings with histopathological results.
- To identify imaging predictors for specific tumor characteristics.
Main Methods:
- Retrospective analysis of CT scans from 17 patients with IBD-related colorectal cancer.
- Correlation of imaging findings with surgical and histopathological data.
- Univariate and multivariate analyses to assess relationships between CT and histopathological variables.
Main Results:
- Two main CT patterns identified: soft tissue mass (Type 1) and circumferential thickening/stenosis (Type 2).
- Type 2 tumors were associated with signet ring cells and proximal colonic dilatation.
- Free fluid on CT was a significant predictor of signet ring cells (OR=50).
Conclusions:
- CT reveals two primary patterns of colorectal cancer in IBD patients.
- Type 2 tumors and the presence of free fluid on CT suggest signet ring cell presence.
- Recognizing these CT features is vital for improving diagnostic accuracy in IBD-related colorectal cancer.
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