Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural changes in polymyositis.

S Matsubara, W G Mair

    Brain : a Journal of Neurology
    |December 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Electron microscopy revealed non-specific muscle fiber changes in polymyositis and dermatomyositis. Chronic cases showed thick filamentous inclusions, and vascular and inflammatory cell changes were prominent in these inflammatory myopathies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nausicaa suture for placenta accreta spectrum: further studies are needed.

    BJOG : an international journal of obstetrics and gynaecology·2018
    Same author

    Matrix changes in articular cartilage in the knee of patients with rheumatoid arthritis after biological therapy: 1-year follow-up evaluation by T2 and T1ρ MRI quantification.

    Clinical radiology·2018
    Same author

    Surgical removal of an isolated femoral metastasis of uterine cervical squamous cell carcinoma: a case report and review of the literature.

    European journal of gynaecological oncology·2018
    Same author

    Uterine-fundal hypoechoic mass: a possible ultrasound sign for cesarean scar pregnancy.

    Clinical and experimental obstetrics & gynecology·2018
    Same author

    Pre-pregnancy cardiovascular indices and birth outcomes of subsequent pregnancies: a 'sequential stress test' revealing hidden cardiovascular weakness?

    BJOG : an international journal of obstetrics and gynaecology·2018
    Same author

    Habitual intake of fermented milk products containing Lactobacillus casei strain Shirota and a reduced risk of hypertension in older people.

    Beneficial microbes·2016

    Area of Science:

    • Neurology
    • Pathology
    • Immunology

    Background:

    • Polymyositis and dermatomyositis are idiopathic inflammatory myopathies.
    • Understanding the ultrastructural pathology is crucial for diagnosis and understanding disease mechanisms.

    Purpose of the Study:

    • To investigate the ultrastructural changes in muscle biopsies from patients with polymyositis and dermatomyositis using electron microscopy.
    • To identify specific ultrastructural markers associated with disease type and chronicity.

    Main Methods:

    • Electron microscopy examination of muscle biopsies from 32 patients diagnosed with polymyositis or dermatomyositis.
    • Detailed analysis of muscle fiber ultrastructure, vascular changes, and inflammatory cell infiltrates.

    Main Results:

    Related Experiment Videos

    • Muscle fibers showed non-specific changes, with minimal structural differences between clinical types.
    • Presence of rough endoplasmic reticulum, annulate lamellae, Golgi apparatus, and thin/thick filamentous inclusions in muscle fibers.
    • Thick filamentous inclusions, often associated with annulate lamellae, were observed in chronic cases.
    • Hypertrophied endothelial cells with inclusions, multi-layered basement membranes, and diverse inflammatory cell infiltrates (macrophages, lymphocytes, plasma cells) were noted.
    • Changes were also observed in intramuscular nerves, motor end-plates, and muscle spindles.

    Conclusions:

    • Ultrastructural findings in polymyositis and dermatomyositis are largely non-specific but reveal characteristic inclusions in chronic stages.
    • Significant vascular and inflammatory cell alterations contribute to the pathology of these inflammatory myopathies.
    • Electron microscopy provides valuable insights into the complex cellular and subcellular changes occurring in the muscle tissue.